We the people express a motion of no confidence in the government

The Conservative government has been a 'zombie' government at best the past 2 years, they have put the British public at risk, they're unable to function as a government in their current form

We can't accept petitions about appointments, which includes calling for a vote of no confidence.

We used to accept petitions that called for a vote of no confidence. However, the Petitions Committee can’t schedule votes of no confidence. This was often frustrating and disappointing for petitioners.

If you're concerned about a particular policy or decision that's the responsibility of Government or the House of Commons, you could start a petition about that.
Petitions calling for action on policy are more likely to be an effective way of achieving the change you want.